The NS5A protein of HCV exerts multiple functions at various stages of the HCV viral life cycle. Different forms of NS5A protein are involved in virion production, interact with host proteins, are implicated in interferon resistance, and in vitro, bind with zinc and HCV RNA. The mechanism of action of NS5A inhibition has been clinically validated at low doses. Importantly, NS5A inhibitors are additive to synergistic in combination with immunomodulatory therapy (IFN and ribavirin) as well as with directly acting antivirals (DAAs.)
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