Achillion Pharmaceuticals

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Complement Factor D Inhibitors

As part of Achillion’s dedication to advancing science, reprints of scientific presentations regarding Achillion’s novel complement factor D inhibitor platform are available here.

Included below are resources that were created as of the dates listed and that reflected management’s views as of such dates. The information contained therein should not be considered current and may not be accurate. Achillion assumes no obligation to update the information in the below resources.

55th ERA-EDTA Congress 2018

May 26, 2018
Factor D Inhibition with ACH-4471 Reduces Complement Alternative Pathway Hyperactivity and Proteinuria in C3 Glomerulopathy: Preliminary Proof-of-Concept Data [Oral presentation]
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May 25, 2018
Complement-Mediated Bactericidal Activity Against Escherichia Coli and Neisseria Meningitidis [Poster presentation]
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2017 American Society of Hematology (ASH) Annual Meeting

December 10, 2017
In vitro combination of ACH-4471 with eculizumab to assess a potential “switch” treatment approach for paroxysmal nocturnal hemoglobinuria
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10th International Conference on Complement Therapeutics

June 24, 2017
Evaluation of mechanisms of paroxysm in paroxysmal nocturnal hemoglobinuria: “Bystander hemolysis” vs. perturbation of soluble regulators
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ASH 2016 PRESENTATIONS

December 5, 2016
Evaluation of bacteria-mediated potential “Bystander” hemolysis of PNH red cells in vitro: No evidence of significant complement classical or lectin pathway-mediated hemolysis induced by microorganisms
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December 5, 2016
Effect of complement inhibition by anti-C5 (eculizumab) or a small molecule inhibitor of Factor D (ACH-4471) on survival of meningococci in blood from vaccinated adults
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INTERNATIONAL COMPLEMENT WORKSHOP PRESENTATIONS

September 5, 2016
Assessment of Complement-Mediated Bacterial Killing and the Effect of a Small Molecule Factor D Inhibitor in Vitro
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September 5, 2016
Comparison of Complement Functional Assays: Differential Sensitivities of Hemolysis and Wieslab Assays to Levels of Complement Proteins C5, Factor B, and Factor D
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EHA 2016 PRESENTATION

June 9, 2016
An Orally Administered Small Molecule Factor D Inhibitor (ACH-4471) For Treatment of PNH, C3G and Complement–Mediated Diseases: Interim Phase 1 Results In Healthy Volunteers
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