Science & Technology

Resources

Complement Factor D Inhibitors

As part of Achillion’s dedication to advancing science, reprints of scientific presentations regarding Achillion’s novel complement factor D inhibitor platform are available here.

Included below are resources that were created as of the dates listed and that reflected management’s views as of such dates. The information contained therein should not be considered current and may not be accurate. Achillion assumes no obligation to update the information in the below resources.

INTERNATIONAL COMPLEMENT WORKSHOP PRESENTATIONS

September 5, 2016
Assessment of Complement-Mediated Bacterial Killing and the Effect of a Small Molecule Factor D Inhibitor in Vitro
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September 5, 2016
Comparison of Complement Functional Assays: Differential Sensitivities of Hemolysis and Wieslab Assays to Levels of Complement Proteins C5, Factor B, and Factor D
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EHA 2016 PRESENTATION

June 9, 2016
An Orally Administered Small Molecule Factor D Inhibitor (ACH-4471) For Treatment of PNH, C3G and Complement–Mediated Diseases: Interim Phase 1 Results In Healthy Volunteers
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ASH 2015 PRESENTATIONS

Complement Factor D Symposium, hosted by Achillion. Event held Sunday, December 6, 2015 during the American Society of Hematology (ASH) Annual Meeting in Orlando, FL.

Milind Deshpande, Ph.D., President and Chief Executive Officer of Achillion, provided the opening remarks at the first Complement Symposium, hosted by Achillion, which was held in Orlando, Florida during the American Society of Hematology 2015 Annual Meeting, December 6, 2015.

Dr. Peter Densen, M.D., Professor of Internal Medicine – Infectious Disease, University of Iowa, provided a detailed look at the role of thecomplement system and the relative risks of infection associated with immune modulation.

Dr. Scott Barnum, Ph.D., Department of Microbiology at the University of Alabama at Birmingham, presented a review of complement immune-biology and the roles of the classical, lectin, and alternative pathways.

Dr. David Apelian, M.D., Ph.D., Chief Medical Officer of Achillion Pharmaceuticals, discussing the nomination of ACH-4471, small-molecule complement factor D inhibitor, being developed for the treatment of ultra-rare diseases, including PNH.


December 6, 2015
Small Molecule Factor D Inhibitors Block Complement Activation in Paroxysmal Nocturnal Hemoglobinuria and Atypical Hemolytic Uremic Syndrome
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ASH 2014 PRESENTATIONS

December 8, 2014
Pharmacology of Complement Factor D Inhibitors ASH 2014
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December 8, 2014
Complement Factor D Inhibitors for PNH ASH 2014
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Please note that the above resources were created as of the dates listed and that reflected management’s views as of such dates. The information contained therein should not be considered current and may not be accurate. Achillion assumes no obligation to update the information in the above resources.